In agreement with the results showing a dependency on caspase-8 and TRAIL-R2/DR5 of the increased sensitivity to ER stress of cells grown on a soft ECM, sensitization of tumor cells to thapsigargin treatment upon YAP/TAZ knockdown was markedly inhibited in cells that had been silenced for the expression of either caspase-8 (Fig. 3B and Supplementary Fig. 2A) or TRAIL-R2/DR5 (Fig. 3C). The gene discussed is CASP8; the disease is neoplasm.