PRS related to metabolic traits (e.g., HDL cholesterol, celiac disease, HbA1c, apolipoprotein A1) as well as cardiovascular disorders (e.g., cardiovascular disease, resting heart rate, ischemic stroke, and atrial fibrillation) also showed significant association with thickness in particular areas of the retina. This evidence concerns the gene APOA1 and atrial fibrillation.