Notably, upregulated Wnt-7b levels are observed in human ICC tumors and mouse ICC models, with evidence suggesting that macrophages are the cellular source of Wnt-7b production in vivo and in vitro.300 Pharmacological or genetic inhibition of Wnt-7b-Fzd7-β-catenin signaling has shown promise in mitigating tumor growth and metastasis.301 In summary, Wnt/β-catenin signaling contributes to the oncogenic process of liver carcinoma. Here, FZD7 is linked to intrahepatic cholangiocarcinoma.