GPT and acute respiratory distress syndrome: Severe ALI requires meeting specific criteria, including an international normalized ratio (INR) of ≥2.0, ALT levels of ≥10 ULN, and total bilirubin (TBiL) levels of ≥3.0 mg/dL without hepatic encephalopathy.405 An increase in the INR indicates a poor prognosis for patients with severe ALI.406 Studies have demonstrated that apart from etiology, bilirubin levels, INR values, and duration of jaundice are effective predictors for poor prognosis in ALI patients with specific thresholds such as duration of jaundice >3 days, TBil>51 μmol/L, and INR > 1.7.407