The accumulation and nuclear shuttling of β-catenin result in its interaction with T-cell factor/lymphoid enhancer factor (TCF/LEF) transcription factors, activating proto-oncogenes such as myelocytomatosis oncogene (c-Myc) and cyclin-D1 (CCND-1) and thus promoting cell proliferation and migration.291 Here, we summarize the crucial roles of Wnt signaling in liver cancer (Fig. 5). Here, CCND1 is linked to liver cancer.