The most prevalent AATD genotype among people of European descent is Pi*ZZ, occurring at a rate of about 1/2,000 to 1/4,000.102 North America reports a Pi*ZZ prevalence ranging from 1/3,000 to 1/5,000, with specific populations like Newfoundland experiencing higher rates, around 1/1,100.103 Conversely, Pi*ZZ prevalence is markedly lower in Asia and Africa: Japan reports a prevalence of 1/300,000, South Korea at 1/280,000, and African Americans at 1/30,000. The gene discussed is SERPINA1; the disease is alpha 1-antitrypsin deficiency.