Histopathologically, CD4 + T cells are situated in the outer layer of granulomas and exert a pivotal role in sarcoidosis [112].Upon recognizing and being activated by antigens, CD4 T cells possess the capacity to differentiate into diverse subsets, encompassing Th1, Th2, Th17, Th17 cells producing IFN-γ, as well as various Tregs, which can either suppress or enhance granulomatous inflammation [113]. Here, CD4 is linked to Granuloma.