MAPT and ichthyosis: Collectively, the summarized findings underscore the importance of finding interventions for DOC that promote neuroplasticity, increase thalamocortical glucose metabolism, attenuate neuroinflammation, clear amyloid-β and phosphorylated tau, decrease inhibitory pallidal output, facilitate thalamocortical activity, and potentiate neurotransmission in the GABAergic, dopaminergic, noradrenergic, serotonergic, and orexinergic systems.