You et al., showed that in GBM, YY1 promotes the expression of the SUMO-specific protease 1 (SENP1) which deSUMOylates methyltransferase-like 3 (METTL3) that adenine-methylates (m6A) MYC mRNA augmenting its expression. Here, METTL3 is linked to glioblastoma.