We utilized the AR2-Pbn regulator elements with the intent of both obtaining hPSMA-tolerant mice and breeding AR2-Pbn-hPSMA mice with AR2-Pbn-c-Myc (Hi-Myc) mice, the latter to determine the effect of increased PSMA on Hi-Myc prostate cancer progression and to develop a model of endogenous murine prostate cancer that we could target with hPSMA-directed p50-IMC. The gene discussed is MYC; the disease is prostate carcinoma.