Remarkably HCAR1 is overexpressed in numerous cancer cell lines and resected tumors from patients (Roland et al, 2014; Stäubert et al 2015; Lee et al, 2016), and promotes tumor proliferation, metastasis, angiogenesis, survival and immune evasion in vivo (Roland et al, 2014; Lee et al, 2016; Feng et al, 2017). Here, HCAR1 is linked to neoplasm.