IAPP and diabetes mellitus: In addition, α-syn interactions with insulin-secretory granule components could involve the formation of Lewy body-like pancreatic inclusions, promote fibril formation of the complex α-syn/IAPP (IAPP, islet amyloid polypeptide, also known as amylin, involved in the regulation glucose homeostasis) which would contribute to β-cell apoptosis development of diabetes [390,395].