APP and amyloidosis: The loss of these transporters would not only cause ATP production to decline by 50%, with a tendency to decrease with disease progression [261], but also promote the accumulation of amyloid plaques, composed of the amyloid precursor protein (APP) product amyloid beta (Aβ), and the intracellular aggregation of the Tau protein [262,263], both distinctive clinical manifestations of this disease [264].