The Rheb/mTORC1 complex stimulates the activity of transcription factors and proteins such as HIF-1α, STAT3, PPAR, SREBP and S6K1, facilitating the activation of various processes that, by different mechanisms (metabolic reprogramming, providing energy, sustaining metabolism and division) all support tumour cell proliferation and survival (figure 3B.6). The gene discussed is HIF1A; the disease is neoplasm.