The ubiquitin‐proteasome system (UPS) selectively degrades the majority of cellular proteins through an ATP‐driven process.[33] UPS protein degradation has been implicated in various kidney diseases, such as AKI, diabetic nephropathy, and CKD.[34] Data from this study suggest that Lgals3 directly interacted with the E3‐ubiquitin ligase Trim21 and prevented PKM2 from undergoing Trim21‐mediated ubiquitination and degradation. This evidence concerns the gene TRIM21 and chronic kidney disease.