The ubiquitin‐proteasome system (UPS) selectively degrades the majority of cellular proteins through an ATP‐driven process.[33] UPS protein degradation has been implicated in various kidney diseases, such as AKI, diabetic nephropathy, and CKD.[34] Data from this study suggest that Lgals3 directly interacted with the E3‐ubiquitin ligase Trim21 and prevented PKM2 from undergoing Trim21‐mediated ubiquitination and degradation. The gene discussed is TRIM21; the disease is diabetic kidney disease.