TP53 and cancer: Additionally, gene set enrichment analysis (GSEA) indicated enrichment not only of cancer-related pathways, such as epithelial-mesenchymal transition, hypoxia, cell cycle, P53 pathway, and KRAS signaling, but also of immune-related pathways, including inflammatory response, cytokine-cytokine receptor interaction, and adhesion molecules (cams) in the high-TMZR-RGPI subgroup (S4e,f Fig).