Notably, most of these 12 prognostic TMZR-RDEGs, including IGFBP6 [34], BDKRB1 [35], SLC43A3 [36], MMP2 [37], HTRA1 [38], MDK [39], MME [40], PTX3 [41], PTPRN2 [42], and FLNC [43], have been reported to play critical roles in the development and invasiveness of GBM. This evidence concerns the gene PTX3 and glioblastoma.