Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed DEG enrichment in “cell growth and death” and “immune system” pathways in YY2‐overexpressing cells (Figure 1F).[23] Validation using CRC cells revealed that YY2 overexpression significantly decreased viability and colony formation potential (Figure 1G,H; Figure S2E,F, Supporting Information), while increasing cell death rates (Figure 1I; Figure S2G, Supporting Information). This evidence concerns the gene YY2 and colorectal carcinoma.