The pyroptosis‐induced inflammatory environment promotes immune cell recruitment, proliferation, and activation, thereby enhancing anti‐tumor immunity and tumor suppressive effect.[29] We performed single‐cell RNA‐sequencing (scRNA‐seq) using tumor lesions formed by YY2‐overexpressing MC38 and control cells to investigate the influence of YY2‐induced pyroptosis on the immune system (Figure 2A). The gene discussed is YY2; the disease is neoplasm.