YY2 and neoplasm: YY2 is a multifunctional transcription factor which regulates stem cells activity and acts as a tumor suppressor.[23, 24, 25, 26] Tissue microarrays revealed downregulation of YY2 in CRC (Figure S1J,K, Supporting Information) along with a positive correlation between YY2 expression and overall survival (Figure S1L, Supporting Information).