Given that overexpressing lamin B2 (LMNB2) could stabilize micronuclei without causing large‐scale structural alternation upon overexpression, we stabilized micronuclei membrane and prevented their rupture by overexpressing LMNB2 as reported previously (Figure 4J).[35, 36]LMNB2 overexpression significantly decreased the accumulation of cytosolic dsDNA (Figure S5C, Supporting Information), AIM2+ micronuclei (Figure 4K), and AIM2/caspase‐1/GSDMD pathway activity in YY2‐overexpressing CRC cells (Figure 4L; Figure S5D, Supporting Information). This evidence concerns the gene LMNB2 and colorectal carcinoma.