Syngeneic graft experiments with MC38 cells overexpressing YY2 showed that BUB1B knockdown abolished the YY2 tumor suppressive effect (Figure 6D), as well as its positive impact on chromosome missegregation, caspase‐1/GSDMD activation, IL‐1β, and cell death rate in syngeneic graft lesions (Figure 6E,F; Figure S10F–H, Supporting Information). Here, BUB1B is linked to neoplasm.