This subsequently triggers absent in melanoma 2 (AIM2)/caspase‐1/gasdermin D (GSDMD)‐mediated pyroptosis, thereby enhancing tumor immunity and the efficacy of anti‐PD‐L1 immunotherapy in both microsatellite instable (MSI) and microsatellite stable (MSS) tumor cells. This evidence concerns the gene CD274 and neoplasm.