For example, RNase 1 has been found to be the ligand for EphA4, which plays a role in maintaining breast cancer stemness.[45] Similarly, RNase 5 is a ligand for EGFR, facilitating pancreatic cancer progression and metastasis.[20] Additionally, RNase 7 has been confirmed as a ligand for ROS1, enhancing HCC tumorigenesis.[21] This raises the possibility that RNASET2 could also act as a ligand for RTKs to promote HCC metastasis. This evidence concerns the gene EPHA4 and breast cancer.