HMGCR and hepatocellular carcinoma: Consistently, WB analysis also displayed that the deficiency of RNASET2 impaired the expression of sterol regulatory element‐binding protein 2 (SREBP2), which is a crucial transcription factor for cholesterol biosynthesis, as well as its downstream target HMGCR, the rate‐limiting enzyme of cholesterol biosynthesis (Figure 2E,F; Figure S3C, Supporting Information).[29, 30, 31, 32, 33, 34] Rescue experiments conducted with RNASET2 overexpression on RNASET2KO HCC cells revealed that the RNASET2 KO‐mediated increase in ABCA1 and APOA1 production were impaired (Figure 2G).