Consistently, WB analysis also displayed that the deficiency of RNASET2 impaired the expression of sterol regulatory element‐binding protein 2 (SREBP2), which is a crucial transcription factor for cholesterol biosynthesis, as well as its downstream target HMGCR, the rate‐limiting enzyme of cholesterol biosynthesis (Figure 2E,F; Figure S3C, Supporting Information).[29, 30, 31, 32, 33, 34] Rescue experiments conducted with RNASET2 overexpression on RNASET2KO HCC cells revealed that the RNASET2 KO‐mediated increase in ABCA1 and APOA1 production were impaired (Figure 2G). This evidence concerns the gene SREBF2 and hepatocellular carcinoma.