RNASE1 and hepatocellular carcinoma: The contrasting roles of RNASET2 and RNase A family members in the regulation of RTKs can be attributed to variations in their distribution, genetic conservation, and substrate specificity.[19] Notably, RNASET2‐mediated RNA cleavage predominantly occurs in lysosomal compartments,[17, 23] whereas RNase A family enzymes primarily function as secretory ligands that activate RTKs.[20, 21, 45] Further investigation is needed to determine the roles of low levels of serum RNASET2 in HCC patients.