While extending our in vitro studies to in vivo settings will be critical to help extrapolate these results to human conditions, the surprising role of ROCK1 in limiting the assembly of p62 complexes and restraining mTORC1 activation and inflammatory responses highlights the challenges of therapeutically targeting these kinases, a feat that is being undertaken for several age-related disorders, including ALS (57, 58). Here, SQSTM1 is linked to amyotrophic lateral sclerosis.