ROCK1 and amyotrophic lateral sclerosis: p62 aggregates are a well-known feature of neurodegenerative disorders like ALS, and p62 can colocalize with other ALS-linked proteins such as TDP-43, SOD1, and C9ORF72 (15), leading us to investigate the presence of these targets in the p62 complexes formed in the absence of ROCK1.