While extending our in vitro studies to in vivo settings will be critical to help extrapolate these results to human conditions, the surprising role of ROCK1 in limiting the assembly of p62 complexes and restraining mTORC1 activation and inflammatory responses highlights the challenges of therapeutically targeting these kinases, a feat that is being undertaken for several age-related disorders, including ALS (57, 58). This evidence concerns the gene ROCK1 and amyotrophic lateral sclerosis.