In agreement with the context-dependent nature of PRC2 regulation of developmentally important loci, increased levels of CCND1 was not observed in the prostate adenocarcinoma cell line LNCaP and the immortalized mouse embryonic cell line NR-6, illustrating that regulation of CCND1 expression by PRC2 is not observed in all cellular lineages. The gene discussed is CCND1; the disease is prostate adenocarcinoma.