Additionally, we observed that GSK126 treatment resulted in increased levels of CCND1 in the breast cancer line MDA-MB-231 and the SV40-immortalized monkey kidney fibroblast cell line COS7 (Figure 6D), suggesting that PRC2 activity can repress CCND1 expression in multiple mammalian cell lineages and species. This evidence concerns the gene CCND1 and breast carcinoma.