Unexpectedly, inactivation of genes encoding members of the TP53 signaling pathway (TFDP1 and HIPK2), SAGA H3 acetylation complex components (KAT2A, TRRAP, TADA3, TAF5L, TADA2B, SGF29, and TADA1), and the Fanconi Anemia complex (FANCA, FANCC, FANCE, FANCF, FANCG, FANCL, and FAAP100), all implicated in DDR, resulted in resistance to colchicine (Figure 2E–G). Here, TAF5L is linked to anemia.