For example, targeting of genes known to play roles in DNA damage repair (DDR) (Groelly et al., 2023; Su et al., 2020), including RAD54L, MUS81, and 16 proteins in the Fanconi Anemia pathway, strongly sensitized cells to camptothecin, which generates protein–DNA adducts (Figure 1B, C). The gene discussed is RAD54L; the disease is Fanconi anemia.