CD4 and Burkitt lymphoma: Pomalidomide has been shown to induce viral expression in lytic EBV latent Burkitts lymphoma cell line models and HTLV-I macaque models (21, 55), and more recently shown to reverse HIV latency in isolated CD4+ T cells from three virally suppressed PLHIV; however, this required a very high concentration of 10 μM, which is unachievable with clinical dosing, and latency reversal was not seen at 1 μM (11).