TMEM175 and Parkinson disease: Disruption in endolysosomal pH can impair trafficking and autophagy, leading to the accumulation of macromolecules such as misfolded proteins, sugars, lipids, and also damaged organelles, a major hallmark of neurodegenerative diseases including Parkinson's disease (PD) and mutations in TMEM175 appear to impact the development of PD (Wie et al. 2021).