TMEM175 and Parkinson disease: Most importantly, they also found that a common human variant in TMEM175, M393T is an LOF (loss‐of‐function) variant of the channel associated with an increased risk of developing PD and enhanced accumulation of pathological α‐synuclein, a known hallmark of PD while the opposite was observed for the GOF (gain‐of‐function) variant Q65P, but only under stress conditions such as starvation (Wie et al. 2021).