The CD14+_HLAlow cluster, which formed the largest proportion of monocytes in anti‐MDA5+ DM patients, exhibited a unique profile with overexpression of canonical ISGs such as IFI27, IFI6, IFITM1 and IFITM3, while showing reduced expression of cytokine/chemokine genes like IL1β and CXCL8 (Figure 4D). Here, CD14 is linked to dermatomyositis.