In line with previous studies, our findings provide further evidence for the involvement of Pax6 in the modulation of social performance and support the view that Pax6 mutant mice could be a relevant model for neurological disorders such as ASD, as previously suggested (Chhabra et al., 2020; Davis et al., 2008; Kikkawa et al., 2019; Kim et al., 2014; Umeda et al., 2010; Yoshizaki et al., 2016), and other conditions characterized by social and sensory processing abnormalities (Arakawa, 2020; Fernández et al., 2018; Magiati et al., 2014; Ricceri et al., 2007; Sledziowska et al., 2020). Here, PAX6 is linked to nervous system disorder.