Also, the POU class homeobox 2 (POU2F2) can modulate the glycolytic reprogramming and GBM development through phosphoinositide-dependent kinase-1 (PDPK1)-dependent PI3K/AKT/mechanistic target of rapamycin (mTOR) pathway (Yang et al., 2021). Here, AKT1 is linked to glioblastoma.