To interpret the potential effects of FBP1 on PI3K/AKT pathway, it has been found that FBP1 is one of the hypoxia-related genes associated with the hypoxia microenvironment in non-small cell lung cancer, which is also related to the PI3K/AKT pathway (Zhang et al., 2021). Here, AKT1 is linked to non-small cell lung carcinoma.