However, when comparing the hybrid and vaccine immunity groups, there was no difference in COVID-19 incidence among those with CD4 counts <350 cells/μl (HR 0.83; 95% CI 0.45–1.52; p = 0.539) or those with HIV viraemia (HR 1.21; 95% CI 0.70–2.1; p = 0.498) (Fig. 3). The gene discussed is CD4; the disease is COVID-19.