Children with overweight/obesity had higher IL-5 (p < 0.001), IL-17A (p = 0.002), IL-22 (p = 0.030), IL-33 (p < 0.001), TNF-α (p = 0.001), and leptin (p < 0.001), and lower IL-10 (p = 0.002) levels compared to normal weight children, indicating that overweight/obesity affects these cytokines regardless of the asthma status. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.