C3 and obesity due to melanocortin 4 receptor deficiency: Similarly, Vezir et al., observed no interaction effect of obesity and asthma on serum inflammatory biomarkers such as C-reactive protein, C3, C4, leptin, resistin, periostin, YKL-40, Type 1, and Type 2 cytokines, although they did find a notable interaction with adiponectin (38).