Instead, the interaction analysis indicated that the presence of obesity in children with asthma primarily led to a modulation of the inflammatory response, as seen with IL-5 levels in children of concurrent asthma and obesity being higher than in those with asthma only, and overweight/obesity only groups but not substantially exceeding the sum of effects seen in either condition alone. The gene discussed is IL5; the disease is obesity due to melanocortin 4 receptor deficiency.