Interestingly, multiple other substance dependence in EAs was significantly associated with SERINC2 variants too, including cocaine dependence (107 SNPs with 2.6×10-5≤p ≤ 0.020 and 6.6×10-4≤q ≤ 0.046; Table 1A), marijuana dependence (213 SNPs with 1.6×10-4≤p ≤ 0.049 and 1.7×10-3≤q ≤ 8.5×10-3; Table 1A), nicotine dependence (85 SNPs with 6.9×10-4≤p ≤ 0.016 and 0.026≤q ≤ 0.049; Table 1A), and multi-substance dependence (rs28742121 and rs28759069: p=1.7×10-3 and q=0.033; data not shown). The gene discussed is SERINC2; the disease is nicotine dependence.