•Out of hospital cardiac arrest (83–89)•Use of vasoactive drugs prior to arrest (81)•Premorbid PCPC > 2 (81)•Duration of CPR (81)•Trauma or neurologic illness as etiology of arrest (94)•Hemato-oncologic disease (94)•Elevated biomarkers: (94–97)−lactic acidemia pre arrest−elevated NfL-1 and UCH-L1 post arrest. Here, UCHL1 is linked to cardiac arrest.