In recent years, SERINC5 has been shown to increase the production of IFN-I (INF–α and IFN-β) through binding with IFN-induced transmembrane proteins 1/2/3 after CSFV infection (Li et al., 2022b), SERINC5 also is proved to increase the production of IFN-I (INF–α) after HIV infection (Passos et al., 2019), and SERINC5 also increases the production of IFN-I (INF–α and IFN-β) through interacting with the MAVS and TRAF6 proteins after Sendai virus infection (Zeng et al., 2021). The gene discussed is TRAF6; the disease is HIV infectious disease.