(Timilsina et al., 2022) reported a reduction in SERINC5 mRNA levels in COVID-19 patients, with notable decreases at 4 hours post-infection in Vero E6 and HEK293T-hACE2 cells, as well as a decline in protein levels at 16 hours post-infection. This evidence concerns the gene SERINC5 and COVID-19.