observe a reduction in SERINC5 mRNA levels in COVID-19 patients, as well as a decrease in SERINC5 mRNA at 4 hours post-infection and a decline in SERINC5 protein levels at 16 hours post-infection in Vero E6 and HEK293T-hACE2 cells. This evidence concerns the gene SERINC5 and COVID-19.