Therefore, the positive loop of IFN-I, MAVS and TRAF6 is dependent on viral infection, and the effect of INF-I on SERINC5 mRNA after various viruses infection should be investigated more in the future, possibly, upon viral infection INF-I can increase the level of SERINC5, and possibly there is a positive feedback loop between SERINC5 and IFN-I. This evidence concerns the gene SERINC5 and viral infectious disease.