CD8A and breast cancer: Figure 3A displays the infiltration of 24 immune cells. With SYNGR4 overexpression, Th2 cell infiltration increased (Figure 3B), while Tcm (Figure 3C), macrophages (Figure 3D), and CD8-positive T cell infiltration decreased. (Figure 3E) Based on the TIDE algorithm to predict the responsiveness of breast cancers with different SYNGR4 expression groups to immunotherapy, breast cancers with SYNGR4 overexpression had a higher responsiveness to immunotherapy (Figure 4).