Whether the immunosuppressive effect of TLR10 on epithelial cells is desirable in patients with severe COVID-19 needs to be investigated in further experiments, as overexpression of TLR10 also leads to downregulation of IFNβ, a key component of the antiviral response that is already suppressed by the elusive mechanism of SARS-CoV-2 (46). This evidence concerns the gene TLR10 and COVID-19.