Upon adjusting for age, gender, diabetes, hypertension, CKD, sepsis, PNI score, neutrophils, hemoglobin, albumin, total bilirubin, BUN, creatinine, inotropes or vasopressors, LVEF, CRRT, ventilation, SOFA and APACHE II (Model 3), the presence of elevated RAR was independently associated with high all-cause mortality (HR: 1.15, 95% CI: 0.98–1.34 for Q2; HR: 1.65, 95% CI: 1.39–1.96 for Q3; HR: 2.16, 95% CI: 1.74–2.68 for Q4 compared with Q1) (p for trend < 0.001) (Table 2). The gene discussed is ALB; the disease is Hypertension.