found that circIGF2BP3 upregulation in NSCLC inhibits CD8+ T‐cell responses and causes tumor immune evasion by regulating the miR‐328‐3p/miR‐3173‐5p/PKP3 axis and stabilizing the PD‐L1 protein in an OTUB1‐dependent manner. Here, CD274 is linked to non-small cell lung carcinoma.