Interestingly, N-acetyltransferase 10 (NAT10) promotes ankyrin repeat and zinc finger peptidyl tRNA hydrolase 1 (ANKZF1) expression through N4-acetylcytidine (ac4C) modification, which in turn regulates YAP1 activity and activates the expression of pro-lymphangiogenic factors to promote lymphangiogenesis and tumor progression in ccRCC (Miao et al., 2024). The gene discussed is YAP1; the disease is nonpapillary renal cell carcinoma.