Regarding lncRNAs, lncHILAR upregulates Jagged-1 and CXCR4 expression by acting as a ceRNA for miR-613/206/1-1-3p, thus activating the Jagged-1/Notch/CXCR4 signaling pathway and promoting RCC cell invasion and metastasis (Hu et al., 2021). The gene discussed is JAG1; the disease is renal cell carcinoma.