Moreover, centrosomal protein 55 (CEP55) could promote the upregulation of E-cadherin and downregulation of N-cadherin and ZEB1 via PI3K/AKT/mTOR pathway, resulting in RCC epithelial-mesenchymal transition (EMT), proliferation, and metastasis (Chen et al., 2019). Here, AKT1 is linked to renal cell carcinoma.