In the multiple regression models, cerebrovascular burden was significantly associated with both MTL volume (Standardized Beta = –0.82, SE = 0.29, p = 0.015) and WM differences (Standardized Beta = 0.62, SE = 0.17, p = 0.004), while AD-type tau burden was not associated with MTL volume (Standardized Beta = 0.36, SE = 0.22, p = 0.14) or WM differences (Standardized Beta = –0.1, SE = 0.13, p = 0.49) (Table 2; Figure 2). Here, MAPT is linked to Alzheimer disease.