ENO2 and Alzheimer disease: 2018). However, no differences in NSE expression between AD and controls have been seen in the temporal cortex tissue by WB analysis (Figure S2). These results were further confirmed by cryo‐EM in both AD and CTRL groups, where EVs visualised in fraction 4 (as representative of all EV‐enriched fractions) displayed a rounded morphology and sizes in a range of 50 and 250 nm. Moreover, there were no differences in the morphology of EVs between AD and control groups (Figure 2D).