TGFB1 and diabetic kidney disease: Although it has been demonstrated that various diabetic substrates (including high glucose, glycosylation end products, and albumin), reactive oxygen species, angiotensin II, and TGF-β1 play important roles in EMT and TIF for patients with DKD, insufficient attention has been paid to the role of immunoglobulins in renal interstitial fibrosis of DKD.