Moreover, the up-regulation of MAP3K1, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, and MAP3K10, along with the down-regulation of MAP3K2, MAP3K3, MAP3K11, MAP3K12, MAP3K13, MAP3K14, and MAP3K15, contributes to cancer development and progression through various mechanistic pathways. The gene discussed is MAP3K12; the disease is cancer.