Following the evaluation of prognostic capabilities and identifying that among the 15 MAPK3 genes, only 6 up-regulated genes, MAP3K1, MAP3K4, MAP3K7, MAP3K8, MAP3K9, and MAP3K10 exhibited prognostic potential in GC patients; we next assessed the diagnostic potential of these 6 genes through ROC curve analysis. The gene discussed is MAP3K8; the disease is gastric cancer.