NFE2L2 and type 1 diabetes mellitus: Similarly, Markelic et al. [50] found that pancreatic islet lipid peroxidation increased and β-cell loss occurred in the STZ-induced T1DM mouse model, and these effects were associated with the downregulation of Nrf2, GPX4, and SLC7A11, the main players in the anti-ferroptosis pathway, while Fer-1 could reduce lipid peroxidation, while upregulating Nrf2, GPX4, and SLC7A11 and ameliorating β-cell loss.