The enrichment of various CD8+ T cell subsets, particularly those expressing PD-1, not expressing TIM-3, and expressing LAG-3, was strongly linked to improvements in OS, consistent with prior research that linked CD8+PD-1+ T cell infiltration with therapeutic responses in proficient mismatch repair colon cancers [30]. This evidence concerns the gene HAVCR2 and malignant colon neoplasm.