The effective scores of CD8+LAG-3+ T cells (surrounding cells: CD8+LAG-3−), CD8+PD-1+ T cells (surrounding cells: CD8+PD-1−), CD8+TIM-3+ T cells (surrounding cells: CD8+TIM-3−), and CD4+FoxP3−CTLA-4+ T cells (surrounding cells: CD4+FoxP3−CTLA-4−) were internally higher in TLS (Fig. 3C, D). The gene discussed is CD8A; the disease is Tumor Lysis Syndrome.