In the TC-TLS, the effective scores of CD8+LAG-3−PD-1−TIM-3− T cells (surrounding cells: CD8+LAG-3−PD-1+TIM-3−), CD8+PD-1−TIM-3+ T cells (surrounding cells: CD8+PD-1−TIM-3−), and CD4+FoxP3+ T cells (surrounding cells: CD4+FoxP3−) were notably higher than those in the tumour and the stroma (Fig. 3B). This evidence concerns the gene CD4 and neoplasm.