CD8+LAG-3−TIM-3−, CD8+PD-1−, CD8+LAG-3−PD-1−TIM-3−, and CD4+CTLA-4−FoxP3−PD-L1− T cells concentrated in the IM-TLS areas and showed reduced in the IM-non-TLS areas. This evidence concerns the gene CD8A and Tumor Lysis Syndrome.