CTLA4 and neoplasm: Within the TC-TLS, there was a greater abundance of various T cell subsets, including CD8+PD-1+, CD8+PD-1+TIM-3−, CD8+LAG-3−PD-1+TIM-3−, CD8+TIM-3-, CD8+LAG-3−TIM-3−, CD4+FoxP3−, CD4+CTLA-4−, and CD4+PD-L1+ T cells, compared with that in the tumour and stromal regions.