AD characteristics, such as Braak stage, NFT burden, and neuritic plaque burden, were also positively correlated with mTOR activation in excitatory neurons (Supplementary Fig. 1B), where APOE4 was associated with increased mTOR expression in excitatory neurons, oligodendrocytes, and pericytes (Supplementary Fig. 1B). This evidence concerns the gene APOE and Alzheimer disease.