Further investigation revealed that independent prognostic factors for 28-day overall survival in patients with sepsis included LCN2 (OR = 1.326, 95% CI 1.019–1.726, P = 0.036), OLFM4 (OR = 1.002, 95% CI 1.000-1.005, P = 0.023), and miR-122-5p (OR = 1.625, 95% CI 1.137–2.322, P = 0.008) (Table S7). The gene discussed is LCN2; the disease is Sepsis.