Olfactomedin 4 (OLFM4) is produced by a specific group of neutrophils, and increased OLFM4 expression has been linked to worse results in individuals with sepsis and ARDS, influencing the body’s inflammatory reaction after tissue damage (Kangelaris et al. 2015; Kassam et al. 2021). Here, OLFM4 is linked to acute respiratory distress syndrome.