To explore whether NUAK1 mediates the immune escape of hepatocellular carcinoma through inducing PD-L1, we conducted an analysis of the expression of CD274 in HCC samples featuring low and high expression of NUAK1, and the correlation between the expression of NUAK1 and CD274 mRNA level was detected using the TCGA database. This evidence concerns the gene NUAK1 and hepatocellular carcinoma.