HMGCR and migraine disorder: Hong et al. found that activation of HMGCR genes was associated with an increased risk of migraine (OR = 1.46, 95% CI= [1.03, 2.07]; P = 0.035), migraine with aura (OR = 2.03, 95% CI = [1.2, 3.42]; P = 0.008), but not migraine without aura (OR = 1.04, 95% CI = [0.6, 1.81]; P = 0.876) [16].