HMGCR and migraine disorder: Finally, Zhang et al. found that HMGCR was significantly associated with the high risk of migraine in both blood (OR = 1.38, 95%CI= [1.21, 1.57]; P < 0.001) and brain (OR = 2.02, 95%CI= [1.49, 2.74]; P < 0.001) [31].