Considering these recent advances in the literature on the effectiveness of statins or HMG-CoA reductase inhibition on migraine prophylaxis, as well as their relationship to lower migraine risk, We conducted the first systematic review and meta-analysis to comprehensively assess the relationship of the HMG-CoA reductase gene with the risk of migraine and the efficacy of statins in migraine patients. Here, HMGCR is linked to migraine disorder.