Based on the information obtained from the Reactome Pathway Database (Supplementary Table 2), the 15 common DEPs identified in PBMCs from patients with T1DM and MS were involved in immune system activity (BTF3, TTR, CD59, CSTB), diseases of the neuronal system (TTR), signal transduction (STMN1, LAMTOR5), metabolism of nucleotides (RPS21), proteins (TTR, ENAM, CD59, RPS21, SRP9) and RNA (SRSF10, RPS21) (see Supplementary Table 2). The gene discussed is TTR; the disease is type 1 diabetes mellitus.