MMP2, LAMC2, LAMA2, COL5A3, COL7A1, CRTAC1, COL28A1, THBS, HMCN2, and SPARCL1 were identified as significantly enriched in GERD among the exclusively upregulated DAPs, as indicated by the ”Extracellular matrix” enrichment term (UniProt Keywords) (Fig. 3D). The gene discussed is THBS1; the disease is gastroesophageal reflux disease.