As shown in Fig. 3E, exclusively downregulated in GERD (Dataset EV3D) corresponding to the enrichment term “Peroxisome” (KEGG) included PRDX5 (an antioxidant enzyme), ACOX3 (involved in β-oxidation of branched-chain fatty acids), ABCD3 (a transporter for importing fatty acids into peroxisomes), SCP2 (critical for lipid transfer and metabolism within peroxisomes), and EPHX2 (detoxifying epoxides) presumably indicating peroxismal dysfunction. This evidence concerns the gene PRDX5 and gastroesophageal reflux disease.