GERD-related inflammation was characterized by neutrophilic granulocytes (with the corresponding markers such as CTSG and ELANE) and, to a lesser extent (compared to EoE), by eosinophils (with the corresponding markers EPX, RNASE2, RNASE3, PRG2, and PRG3) (Fig. 3A,, B). The gene discussed is ELANE; the disease is gastroesophageal reflux disease.