MMP2, LAMC2, LAMA2, COL5A3, COL7A1, CRTAC1, COL28A1, THBS, HMCN2, and SPARCL1 were identified as significantly enriched in GERD among the exclusively upregulated DAPs, as indicated by the ”Extracellular matrix” enrichment term (UniProt Keywords) (Fig. 3D). Here, LAMA2 is linked to gastroesophageal reflux disease.