A total of 309 proteins (Dataset EV5A) showed increased abundance in all esophagitis subtypes such as COL1A1, COL3A1, COL4A1, COL5A1, COL6A1, FN1, LAMB2, LAMA5, HSPG2, RAC2, and CAV1 with associated and interconnected enrichment terms “ECM-receptor interaction” (KEGG), “Collagen chain trimerization” (RP), and “Focal adhesion” (KEGG) (Fig. 5A; Dataset EV5B). Here, HSPG2 is linked to esophagitis.