We also observed increased levels of CLC, COL1A2, CTSC, EPPK1, and EPX and lowered levels of ALOX12, ENDOU, and GRPEL2, however, these changes were not EoE-specific in our patient cohort and also occurred in CD and/ or GERD (Fig. EV3A; Dataset EV2C). This evidence concerns the gene ALOX12 and gastroesophageal reflux disease.