Besides macrophages, tumor-derived EVs could also exert immunoinhibitory effects on human T cells,82 enhance the cytotoxicity of NK cells,83 and differentially reprogram human DCs.84 Mrizak et al.85 revealed for the first time that NPC-derived exosomes carry the CCL20 chemokine, which can recruit Tregs to the tumor. The gene discussed is CCL20; the disease is neoplasm.