Importantly, the majority of MANA-specific TIL resided in similar TRM clusters in both cancers (84.62% for NSCLC and 59.78% for melanoma; Fig. 1D, E), characterized by expression of CD103, CXCL13, ZNF683, and ENTPD1 (CD39). This evidence concerns the gene ITGAE and non-small cell lung carcinoma.