Several studies have documented transcriptomic features that are distinct in tumor-specific T cells among global TIL, including but not limited to higher levels of CXCL1310 and ENTPD1 (CD39)2,11 and genes encoding multiple immune checkpoints associated with both T cell activation and “exhaustion” or “dysfunction”, as well as lower expression of the IL-7 receptor (IL7R). Here, IL7R is linked to neoplasm.