To investigate the transcriptomic landscape of tumor-specific TIL across two tumor types with distinct clinical and biological characteristics, we performed an integrated transcriptomic analysis of CD8+ TIL at the single cell level from resectable NSCLCs and melanomas from which large numbers of MANA-specific TIL were previously identified and validated (Supplementary Data 1,2)8,9. The gene discussed is CD8A; the disease is melanoma.