MAPT and Alzheimer disease: The blockage of autophagy can induce tau accumulation and aggregation in neurodegenerative processes, which was observed in in vivo and in vitro models of tauopathies (Liu et al. 2009; Salama et al. 2018; Silva et al. 2019) and in post-mortem brains from AD patients (Piras et al. 2016; Long et al. 2020).