FBN1 and heart failure: In a study by Cook et al., it was demonstrated in a mouse model of MFS that reduced fibrillin-1 production by cardiomyocytes is sufficient to precipitate dilative cardiomyopathy in cardiomyocytes.9 Furthermore, deficient fibrillin-1 leads to altered myocardial transforming growth factor-β (TGF-β), which can lead to myocardial structural changes due to its association with fibrosis in pressure loaded heart failure.9 While MFS cardiomyopathy has been mainly shown in the adult population, recent studies have described it in the pediatric population.