MAP2 and schizophrenia: If we consider Poly (I:C) NSCs as a cellular model of neurodevelopmental disease and compare our MAP2 data with those obtained from studies using postmortem brain samples from individuals with schizophrenia and other animal models engineered to exhibit permanent alterations in this protein [47, 49], we observe that hyperphosphorylation of MAP2 is a consistent and distinctive feature across all cases.