RECQL4 and Rothmund-Thomson syndrome: Mutations in RECQ4 have been identified as a causative agent for three autosomal recessive diseases, Rothmund-Thomson (RTS), Baller-Gerold, and RAPADILINO syndromes characterised by growth deficiency, poikiloderma, and higher predisposition to osteosarcomas along with greater malignancy rate21,22.