Four of these enzymes—SIRT1, SIRT2, SIRT6, and SIRT7—erase histone lysine acetylation (Kac) to regulate chromatin structure and gene transcription, and they have isozyme-specific roles as epigenetic regulators of disease pathways in cancer, neurodegeneration, and cardiometabolic disorders3,5,6. This evidence concerns the gene SIRT7 and cancer.