KCNH2 and cancer: Despite speculations, data here provided clearly show that the hERG1/β1 integrin complex behave as a molecular device in cancer cells to regulate cell proliferation and migration Indeed, inhibiting the integrity and/or formation of lipid rafts, with either MβCD and combining these treatments with the bispecific antibody which harnesses and dissociates the hERG1/β1 integrin complex [41, 46] we obtained a strong reduction of both PDAC cell proliferation and migration.